InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTG2

Summary

InnateDB Protein

IDBP-598918.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTG2

Protein Name

BTG family, member 2

Synonyms

PC3; TIS21;

Species

Homo sapiens

Ensembl Protein

ENSP00000433553

InnateDB Gene

IDBG-105945 (BTG2)

Protein Structure

UniProt Annotation

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269PubMed:12771185, ECO:0000269PubMed:15788397, ECO:0000269PubMed:18337750, ECO:0000269PubMed:18773938, ECO:0000269PubMed:23236473}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0008285	negative regulation of cell proliferation
GO:0017148	negative regulation of translation
GO:0031175	neuron projection development
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening