InnateDB Protein
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IDBP-599377.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EID3
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Protein Name
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EP300 interacting inhibitor of differentiation 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000435619
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InnateDB Gene
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IDBG-547202 (EID3)
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Protein Structure
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Function |
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269PubMed:15987788}.Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300- dependent transcription factors. {ECO:0000269PubMed:15987788}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15987788}. Cytoplasm {ECO:0000269PubMed:15987788}. Chromosome, telomere {ECO:0000305PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269PubMed:15987788}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. {ECO:0000269PubMed:15987788}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014854
Non-structural maintenance of chromosome element 4, C-terminal
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PFAM |
PF08743
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N140
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PhosphoSite |
PhosphoSite-Q8N140
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
493861
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UniGene |
Hs.740041
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RefSeq |
NP_001008395
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HUGO |
HGNC:32961
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OMIM |
612986
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CCDS |
CCDS53822
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HPRD |
17415
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IMGT |
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EMBL |
AK098698
BC027612
CH471054
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GenPept |
AAH27612
BAC05385
EAW97747
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