Version 5.4
Homo sapiens Protein: EID3
Summary
InnateDB Protein IDBP-599377.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EID3
Protein Name EP300 interacting inhibitor of differentiation 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435619
InnateDB Gene IDBG-547202 (EID3)
Protein Structure
UniProt Annotation
Function Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. {ECO:0000269PubMed:15987788}.Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300- dependent transcription factors. {ECO:0000269PubMed:15987788}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15987788}. Cytoplasm {ECO:0000269PubMed:15987788}. Chromosome, telomere {ECO:0000305PubMed:15987788}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269PubMed:15987788}.
Disease Associations
Tissue Specificity Highly expressed in testis. {ECO:0000269PubMed:15987788}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID
InterPro IPR014854 Non-structural maintenance of chromosome element 4, C-terminal
PFAM PF08743
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N140
PhosphoSite PhosphoSite-Q8N140
TrEMBL
UniProt Splice Variant
Entrez Gene 493861
UniGene Hs.740041
RefSeq NP_001008395
HUGO HGNC:32961
OMIM 612986
CCDS CCDS53822
HPRD 17415
IMGT
EMBL AK098698 BC027612 CH471054
GenPept AAH27612 BAC05385 EAW97747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca