InnateDB Protein
|
IDBP-5996.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ATP5I
|
Protein Name
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
|
Synonyms
|
ATP5K;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000306003
|
InnateDB Gene
|
IDBG-5992 (ATP5I)
|
Protein Structure
|
|
Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
|
Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
11
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
GO:0000276
|
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
|
GO:0005739
|
mitochondrion
|
GO:0005743
|
mitochondrial inner membrane
|
GO:0005753
|
mitochondrial proton-transporting ATP synthase complex
|
|
PDB ID |
|
InterPro |
IPR008386
ATPase, F0 complex, subunit E, mitochondrial
|
PFAM |
PF05680
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P56385
|
PhosphoSite |
PhosphoSite-P56385
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
521
|
UniGene |
|
RefSeq |
NP_009031
|
HUGO |
HGNC:846
|
OMIM |
601519
|
CCDS |
CCDS3337
|
HPRD |
03308
|
IMGT |
|
EMBL |
BC003679
BC105610
BT006922
D50371
|
GenPept |
AAH03679
AAI05611
AAP35568
BAA23322
|
|
|