InnateDB Protein
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IDBP-599643.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP20
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Protein Name
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Rho GTPase activating protein 20
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437905
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InnateDB Gene
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IDBG-70710 (ARHGAP20)
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Protein Structure
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Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.
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Tissue Specificity |
Expressed predominantly in the brain. Lower expression is found in lymph nodes. {ECO:0000269PubMed:15543602}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0007165
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signal transduction
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GO:0007264
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small GTPase mediated signal transduction
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GO:0043547
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positive regulation of GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P2F6
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PhosphoSite |
PhosphoSite-Q9P2F6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57569
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UniGene |
Hs.739502
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RefSeq |
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HUGO |
HGNC:18357
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OMIM |
609568
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CCDS |
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HPRD |
10657
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IMGT |
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EMBL |
AB037812
AK292290
AY496263
AY496264
AY496265
AY496266
AY496267
BC039340
CH471065
EF444953
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GenPept |
AAH39340
AAS45466
AAS45467
AAS45468
AAS45469
AAS45470
ACA05945
ACA05946
BAA92629
BAF84979
EAW67134
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