InnateDB Protein
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IDBP-599673.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAS2R38
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Protein Name
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taste receptor, type 2, member 38
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Synonyms
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PTC; T2R38; T2R61;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000448219
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InnateDB Gene
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IDBG-546991 (TAS2R38)
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Protein Structure
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Function |
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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GO:0033038
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bitter taste receptor activity
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Biological Process |
GO:0001580
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detection of chemical stimulus involved in sensory perception of bitter taste
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0050909
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sensory perception of taste
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Cellular Component |
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PDB ID |
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InterPro |
IPR007960
Mammalian taste receptor
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PFAM |
PF05296
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P59533
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PhosphoSite |
PhosphoSite-P59533
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TrEMBL |
Q50KM3
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UniProt Splice Variant |
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Entrez Gene |
5726
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UniGene |
Hs.647085
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RefSeq |
NP_789787
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HUGO |
HGNC:9584
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OMIM |
607751
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CCDS |
CCDS34765
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HPRD |
09672
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IMGT |
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EMBL |
AB199146
AB199148
AF494231
AY114095
AY258598
AY724960
BC104933
BC104937
CH236950
CH471070
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GenPept |
AAI04934
AAI04938
AAM19322
AAM63545
AAP14667
AAU21156
BAD98025
BAD98027
EAL24011
EAW83993
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