InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PYGL

Summary

InnateDB Protein

IDBP-599887.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYGL

Protein Name

phosphorylase, glycogen, liver

Synonyms

GSD6;

Species

Homo sapiens

Ensembl Protein

ENSP00000443787

InnateDB Gene

IDBG-6391 (PYGL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002060	purine nucleobase binding
GO:0004645	phosphorylase activity
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0008144	drug binding
GO:0008184	glycogen phosphorylase activity
GO:0016208	AMP binding
GO:0019842	vitamin binding
GO:0030170	pyridoxal phosphate binding
GO:0032052	bile acid binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006006	glucose metabolic process
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000811 Glycosyl transferase, family 35
IPR011833 Glycogen/starch/alpha-glucan phosphorylase

PFAM

PF00343

PRINTS

PIRSF

PIRSF000460

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-P06737

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF046785 AF046787 AF046788 AF046789 AF046790 AF046791 AF046792 AF046793 AF046794 AF046795 AF046796 AF046797 AF046798 AF066858 AK300580 AL358334 BC009895 BC082229 BC095850 BC110791 CH471078 M14636 M36807 Y15233

GenPept

AAA35906 AAA52577 AAC17450 AAC18079 AAC23504 AAH09895 AAH82229 AAH95850 AAI10792 BAG62279 CAA75517 EAW65685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca