InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BACH2

Summary

InnateDB Protein

IDBP-600016.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACH2

Protein Name

BTB and CNC homology 1, basic leucine zipper transcription factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000437473

InnateDB Gene

IDBG-94358 (BACH2)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. {ECO:0000250, ECO:0000269PubMed:17018862}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17018862}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00978, ECO:0000269PubMed:17018862}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.

Disease Associations

Tissue Specificity

B-cell specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ

PFAM

PF00170
PF07716
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BYV9