InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD8B

Summary

InnateDB Protein

IDBP-60049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD8B

Protein Name

CD8b molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375070

InnateDB Gene

IDBG-60041 (CD8B)

Protein Structure

UniProt Annotation

Function

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 5: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 6: Secreted {ECO:0000305}.Isoform 7: Secreted {ECO:0000305}.Isoform 8: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells. {ECO:0000269PubMed:8436166}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0042288	MHC class I protein binding

Biological Process

GO:0006955	immune response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016032	viral process
GO:0042110	T cell activation
GO:0050690	regulation of defense response to virus by virus
GO:0050776	regulation of immune response

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031901	early endosome membrane
GO:0042101	T cell receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P10966