Version 5.4
Homo sapiens Protein: GNE
Summary
InnateDB Protein IDBP-601122.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNE
Protein Name glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms DMRV; GLCNE; IBM2; NM; Uae1;
Species Homo sapiens
Ensembl Protein ENSP00000437765
InnateDB Gene IDBG-65042 (GNE)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005524 ATP binding
GO:0009384 N-acylmannosamine kinase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006045 N-acetylglucosamine biosynthetic process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006054 N-acetylneuraminate metabolic process
GO:0007155 cell adhesion
GO:0009103 lipopolysaccharide biosynthetic process
GO:0046380 N-acetylneuraminate biosynthetic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000600 ROK
IPR001312 Hexokinase
IPR003331 UDP-N-acetylglucosamine 2-epimerase
IPR020004 UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing
PFAM PF00480
PF02350
PRINTS PR00475
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y223
PhosphoSite PhosphoSite-Q9Y223
TrEMBL
UniProt Splice Variant
Entrez Gene 10020
UniGene Hs.692475
RefSeq NP_001177317
HUGO HGNC:23657
OMIM 603824
CCDS CCDS55310
HPRD 04825
IMGT
EMBL AF051852 AF155663 AF317635 AJ238764 AK295562 AK296687 AK312539 AL158830 AM697708 AM697709 BC121179 CH471071 EU093084
GenPept AAD32251 AAD38197 AAG31661 AAI21180 ABU55403 BAG35438 BAH12108 BAH12414 CAB42607 CAM91424 CAM91425 EAW58307 EAW58309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca