InnateDB Protein
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IDBP-601353.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MEFV
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Protein Name
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Mediterranean fever
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Synonyms
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FMF; MEF; TRIM20;
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Species
|
Homo sapiens
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Ensembl Protein
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ENSP00000438711
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InnateDB Gene
|
IDBG-11729 (MEFV)
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Protein Structure
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|
Function |
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
20
[view]
|
Protein-Protein |
18
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
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|
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Molecular Function |
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Biological Process |
GO:0006954
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inflammatory response
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GO:0032691
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negative regulation of interleukin-1 beta production
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GO:0032695
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negative regulation of interleukin-12 production
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GO:0035872
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nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
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GO:0045087
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innate immune response (InnateDB)
|
GO:0050728
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negative regulation of inflammatory response
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GO:0071641
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negative regulation of macrophage inflammatory protein 1 alpha production
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GO:2001056
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positive regulation of cysteine-type endopeptidase activity
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|
Cellular Component |
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PDB ID |
|
InterPro |
IPR000315
Zinc finger, B-box
IPR004020
DAPIN domain
IPR011029
Death-like domain
|
PFAM |
PF00643
PF02758
|
PRINTS |
|
PIRSF |
|
SMART |
SM00336
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TIGRFAMs |
|
Modification |
|
SwissProt |
O15553
|
PhosphoSite |
PhosphoSite-O15553
|
TrEMBL |
I4DSV7
|
UniProt Splice Variant |
|
Entrez Gene |
4210
|
UniGene |
Hs.632221
|
RefSeq |
NP_001185465
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HUGO |
HGNC:6998
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OMIM |
608107
|
CCDS |
CCDS55981
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HPRD |
02012
|
IMGT |
|
EMBL |
AB726085
AF018080
AF111163
AF301150
AF301151
AJ003147
BC101511
BC101537
CH471112
Y14441
|
GenPept |
AAB70557
AAD26152
AAI01512
AAI01538
AAK97223
AAK97224
BAM20997
CAA05906
CAA74793
EAW85382
EAW85383
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