InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMC3

Summary

InnateDB Protein

IDBP-601614.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMC3

Protein Name

proteasome (prosome, macropain) 26S subunit, ATPase, 3

Synonyms

TBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000433097

InnateDB Gene

IDBG-43355 (PSMC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 132 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	132 [view]
Protein-Protein	131 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030163	protein catabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005937 26S proteasome subunit P45
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite