Version 5.4
Homo sapiens Protein: GCN1L1
Summary
InnateDB Protein IDBP-60168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCN1L1
Protein Name GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
Synonyms GCN1; GCN1L; PRIC295;
Species Homo sapiens
Ensembl Protein ENSP00000300648
InnateDB Gene IDBG-60166 (GCN1L1)
Protein Structure
UniProt Annotation
Function Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:9039502}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 78 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006417 regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000357 HEAT
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
IPR022716 Domain of unknown function DUF3554
PFAM PF02985
PF12074
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92616
PhosphoSite PhosphoSite-Q92616
TrEMBL B4DM32
UniProt Splice Variant
Entrez Gene 10985
UniGene Hs.298716
RefSeq NP_006827
HUGO HGNC:4199
OMIM 605614
CCDS CCDS41847
HPRD 16127
IMGT
EMBL AC004812 AK297271 BC021129 BC032335 BC046177 BC064346 BC153881 D86973 U77700 U88836 U88837
GenPept AAC51648 AAC83183 AAD00655 AAD00656 AAH21129 AAH32335 AAH46177 AAH64346 AAI53882 BAA13209 BAG59744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca