InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2AK4

Summary

InnateDB Protein

IDBP-602020.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2AK4

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453148

InnateDB Gene

IDBG-5997 (EIF2AK4)

Protein Structure

UniProt Annotation

Function

Can phosphorylate the alpha subunit of EIF2 and may mediate translational control. {ECO:0000250}.

Subcellular Localization

Disease Associations

Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2) [MIM:234810]: A disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension. {ECO:0000269PubMed:24135949, ECO:0000269PubMed:24292273}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in the lung in smooth muscle cells of the pulmonary vessel wall, interstitial tissue and macrophages. {ECO:0000269PubMed:10504407, ECO:0000269PubMed:24292273}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006446	regulation of translational initiation
GO:0006468	protein phosphorylation

Cellular Component

GO:0022626

cytosolic ribosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006575 RWD domain
IPR011009 Protein kinase-like domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF05773

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00591
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt