Version 5.4
Homo sapiens Protein: PLXDC2
Summary
InnateDB Protein IDBP-60233.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXDC2
Protein Name plexin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366450
InnateDB Gene IDBG-60229 (PLXDC2)
Protein Structure
UniProt Annotation
Function May play a role in tumor angiogenesis. {ECO:0000269PubMed:11559528}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue. {ECO:0000269PubMed:11559528}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002165 Plexin
IPR016201 Plexin-like fold
PFAM PF01437
PRINTS
PIRSF
SMART SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UX71
PhosphoSite PhosphoSite-Q6UX71
TrEMBL
UniProt Splice Variant
Entrez Gene 84898
UniGene Hs.658134
RefSeq NP_001269665
HUGO HGNC:21013
OMIM 606827
CCDS CCDS60497
HPRD 08440
IMGT
EMBL AC067743 AC069549 AF378757 AK027529 AL353147 AY358486 BC012885
GenPept AAH12885 AAL11994 AAQ88850 BAB55178 CAH71083 CAH71084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca