InnateDB Protein
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IDBP-602340.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DRAM2
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Protein Name
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DNA-damage regulated autophagy modulator 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437718
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InnateDB Gene
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IDBG-101012 (DRAM2)
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Protein Structure
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Function |
Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000269PubMed:19895784}.
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Subcellular Localization |
Lysosome membrane {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}; Multi- pass membrane protein {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}.
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Disease Associations |
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Tissue Specificity |
Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus. {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019402
Frag1/DRAM/Sfk1
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PFAM |
PF10277
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UX65
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PhosphoSite |
PhosphoSite-Q6UX65
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TrEMBL |
S4R2Z2
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UniProt Splice Variant |
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Entrez Gene |
128338
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UniGene |
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RefSeq |
NP_848549
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HUGO |
HGNC:28769
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OMIM |
613360
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CCDS |
CCDS30801
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HPRD |
14685
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IMGT |
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EMBL |
AK075350
AL355816
AY336747
AY358492
BC047025
BC091509
CH471122
EF710624
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GenPept |
AAH47025
AAH91509
AAQ88856
AAR02410
ABR27678
BAC11562
CAI19366
EAW56464
EAW56467
EAW56468
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