InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TUBA1A

Summary

InnateDB Protein

IDBP-602432.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUBA1A

Protein Name

tubulin, alpha 1a

Synonyms

B-ALPHA-1; LIS3; TUBA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000446637

InnateDB Gene

IDBG-31211 (TUBA1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	207 [view]
Protein-Protein	207 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006457	protein folding
GO:0007017	microtubule-based process
GO:0030705	cytoskeleton-dependent intracellular transport
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding
GO:0051258	protein polymerization
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

PFAM

PF00091
PF03953

PRINTS

PR01161
PR01162
PR01163
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt