Version 5.4
Homo sapiens Protein: CST1
Summary
InnateDB Protein IDBP-60285.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST1
Protein Name cystatin SN
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305731
InnateDB Gene IDBG-60283 (CST1)
Protein Structure
UniProt Annotation
Function Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Subcellular Localization Secreted {ECO:0000269PubMed:20189825}.
Disease Associations
Tissue Specificity Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269PubMed:20189825}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01037
PhosphoSite PhosphoSite-P01037
TrEMBL
UniProt Splice Variant
Entrez Gene 1469
UniGene
RefSeq NP_001889
HUGO HGNC:2473
OMIM 123855
CCDS CCDS13160
HPRD 00460
IMGT
EMBL AL591074 BC021225 J03870 M19169
GenPept AAA36115 AAA60299 AAH21225 CAC94783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca