InnateDB Protein
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IDBP-60285.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CST1
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Protein Name
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cystatin SN
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305731
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InnateDB Gene
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IDBG-60283 (CST1)
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Protein Structure
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Function |
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:20189825}.
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Disease Associations |
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Tissue Specificity |
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269PubMed:20189825}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004869
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cysteine-type endopeptidase inhibitor activity
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Biological Process |
GO:0001580
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detection of chemical stimulus involved in sensory perception of bitter taste
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GO:0010951
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negative regulation of endopeptidase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000010
Proteinase inhibitor I25, cystatin
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PFAM |
PF00031
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PRINTS |
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PIRSF |
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SMART |
SM00043
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TIGRFAMs |
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Modification |
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SwissProt |
P01037
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PhosphoSite |
PhosphoSite-P01037
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1469
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UniGene |
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RefSeq |
NP_001889
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HUGO |
HGNC:2473
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OMIM |
123855
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CCDS |
CCDS13160
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HPRD |
00460
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IMGT |
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EMBL |
AL591074
BC021225
J03870
M19169
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GenPept |
AAA36115
AAA60299
AAH21225
CAC94783
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