Version 5.4
Homo sapiens Protein: FGFR1OP2
Summary
InnateDB Protein IDBP-602867.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFR1OP2
Protein Name FGFR1 oncogene partner 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437556
InnateDB Gene IDBG-24333 (FGFR1OP2)
Protein Structure
UniProt Annotation
Function May be involved in wound healing pathway. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Tissue Specificity Expressed in bone marrow, spleen and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR008555 Suppressor of IKBKE 1
PFAM PF05769
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVK5
PhosphoSite PhosphoSite-Q9NVK5
TrEMBL F5GX47
UniProt Splice Variant
Entrez Gene 26127
UniGene Hs.602646
RefSeq NP_001165359
HUGO HGNC:23098
OMIM 608858
CCDS CCDS53766
HPRD 10589
IMGT
EMBL AC024093 AC024896 AF161472 AK001534 AL117608 AY506561 BC032143
GenPept AAF29087 AAH32143 AAR91611 BAA91745 CAB56012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca