Version 5.4
Homo sapiens Protein: RHEBL1
Summary
InnateDB Protein IDBP-602921.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHEBL1
Protein Name Ras homolog enriched in brain like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446726
InnateDB Gene IDBG-30982 (RHEBL1)
Protein Structure
UniProt Annotation
Function Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000269PubMed:12869548, ECO:0000269PubMed:16098514, ECO:0000269PubMed:16328882, ECO:0000269PubMed:17162089}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:16328882}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines. {ECO:0000269PubMed:16006564, ECO:0000269PubMed:16328882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007264 small GTPase mediated signal transduction
GO:0031929 TOR signaling
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAI7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 121268
UniGene Hs.159013
RefSeq XP_005268691
HUGO HGNC:21166
OMIM
CCDS
HPRD 15245
IMGT
EMBL AK098663 AY327412 AY509932 BC027482 CH471111
GenPept AAH27482 AAP92804 AAS80166 BAC05370 EAW58038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca