InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP4K5

Summary

InnateDB Protein

IDBP-6031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K5

Protein Name

mitogen-activated protein kinase kinase kinase kinase 5

Synonyms

GCKR; KHS; KHS1; MAPKKKK5;

Species

Homo sapiens

Ensembl Protein

ENSP00000013125

InnateDB Gene

IDBG-6029 (MAP4K5)

Protein Structure

UniProt Annotation

Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269PubMed:9038372}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9038372}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. {ECO:0000269PubMed:9038372}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0007257	activation of JUN kinase activity
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt