Homo sapiens Protein: LGR5 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-603399.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | LGR5 | ||||||||||||||||||||||
Protein Name | leucine-rich repeat containing G protein-coupled receptor 5 | ||||||||||||||||||||||
Synonyms | FEX; GPR49; GPR67; GRP49; HG38; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000441035 | ||||||||||||||||||||||
InnateDB Gene | IDBG-47982 (LGR5) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269PubMed:21693646, ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076, ECO:0000269PubMed:22815884, ECO:0000269PubMed:23809763}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269PubMed:23439653}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. {ECO:0000269PubMed:12601349, ECO:0000269PubMed:16575208, ECO:0000269PubMed:19030762}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000372 Leucine-rich repeat-containing N-terminal IPR001611 Leucine-rich repeat IPR002131 Glycoprotein hormone receptor family IPR003591 Leucine-rich repeat, typical subtype IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
PF01462 PF00560 PF13504 PF13855 |
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PRINTS |
PR00237
PR00373 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00013
SM00369 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O75473 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O75473 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8549 | ||||||||||||||||||||||
UniGene | Hs.658889 | ||||||||||||||||||||||
RefSeq | NP_001264155 | ||||||||||||||||||||||
HUGO | HGNC:4504 | ||||||||||||||||||||||
OMIM | 606667 | ||||||||||||||||||||||
CCDS | CCDS61194 | ||||||||||||||||||||||
HPRD | 05979 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC078860 AC090116 AF061444 AF062006 BC096324 BC096325 BC096326 BC099650 FN820440 | ||||||||||||||||||||||
GenPept | AAC28019 AAC77911 AAH96324 AAH96325 AAH96326 AAH99650 CBL95002 | ||||||||||||||||||||||