Homo sapiens Protein: GPR17 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-603451.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | GPR17 | ||||||
Protein Name | G protein-coupled receptor 17 | ||||||
Synonyms | |||||||
Species | Homo sapiens | ||||||
Ensembl Protein | ENSP00000442982 | ||||||
InnateDB Gene | IDBG-69246 (GPR17) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. {ECO:0000269PubMed:16990797}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. {ECO:0000269PubMed:16990797}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | |||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR003912 Protease-activated receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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PFAM |
PF00001
PF10320 |
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PRINTS |
PR00237
PR01428 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q13304 | ||||||
PhosphoSite | PhosphoSite-Q13304 | ||||||
TrEMBL | G4XH68 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 2840 | ||||||
UniGene | Hs.46453 | ||||||
RefSeq | NP_001154887 | ||||||
HUGO | HGNC:4471 | ||||||
OMIM | 603071 | ||||||
CCDS | CCDS2148 | ||||||
HPRD | 04351 | ||||||
IMGT | |||||||
EMBL | AC010976 AC074114 AK292725 AK313949 BC031653 BC039595 CH471103 JF810891 U33447 Y12546 Z94154 Z94155 | ||||||
GenPept | AAB16746 AAH31653 AEP43758 BAF85414 BAG36667 CAA73144 CAB08107 CAB08108 EAW95337 | ||||||