Version 5.4
Homo sapiens Protein: COQ7
Summary
InnateDB Protein IDBP-603493.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COQ7
Protein Name coenzyme Q7 homolog, ubiquinone (yeast)
Synonyms CAT5; CLK-1; CLK1;
Species Homo sapiens
Ensembl Protein ENSP00000442923
InnateDB Gene IDBG-17528 (COQ7)
Protein Structure
UniProt Annotation
Function Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed dominantly in heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro IPR009078 Ferritin-like superfamily
IPR011566 Ubiquinone biosynthesis protein Coq7
PFAM PF03232
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99807
PhosphoSite PhosphoSite-Q99807
TrEMBL H3BTN8
UniProt Splice Variant
Entrez Gene 10229
UniGene Hs.664046
RefSeq NP_001177912
HUGO HGNC:2244
OMIM 601683
CCDS CCDS53993
HPRD 03401
IMGT
EMBL AC099518 AF032900 AF098948 AK024291 AK315470 AL136647 BC003185 CH471186 U81276
GenPept AAC51120 AAC69451 AAD43648 AAH03185 BAB14876 BAG37856 CAB66582 EAW50268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca