Version 5.4
Homo sapiens Protein: DEFA4
Summary
InnateDB Protein IDBP-6056.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFA4
Protein Name defensin, alpha 4, corticostatin
Synonyms DEF4; HNP-4; HP-4; HP4;
Species Homo sapiens
Ensembl Protein ENSP00000297435
InnateDB Gene IDBG-6052 (DEFA4)
Protein Structure
UniProt Annotation
Function Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. {ECO:0000269PubMed:15616305, ECO:0000269PubMed:15620707}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of other organism
GO:0045087 innate immune response (InnateDB)
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
Protein Structure and Domains
PDB ID
InterPro IPR002366 Defensin propeptide
IPR006080 Beta defensin/Neutrophil defensin
IPR006081 Mammalian defensins
IPR016327 Alpha-defensin
PFAM PF00879
PF00323
PRINTS
PIRSF PIRSF001875
SMART SM00048
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12838
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1669
UniGene Hs.591391
RefSeq NP_001916
HUGO HGNC:2763
OMIM 601157
CCDS CCDS5961
HPRD 03099
IMGT
EMBL AF200455 BC093959 BC106747 BC112091 CH471153 U18745 X65977
GenPept AAA64488 AAH93959 AAI06748 AAI12092 AAT68877 CAA46792 EAW80486

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca