InnateDB Protein
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IDBP-60640.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PROP1
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Protein Name
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PROP paired-like homeobox 1
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Synonyms
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CPHD2; PROP-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000311290
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InnateDB Gene
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IDBG-60638 (PROP1)
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Protein Structure
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Function |
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
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Disease Associations |
Pituitary hormone deficiency, combined, 2 (CPHD2) [MIM:262600]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD2 is characterized by pleiotropic deficiencies of growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, prolactin and adrenocorticotropic hormone. {ECO:0000269PubMed:10946881, ECO:0000269PubMed:11549703, ECO:0000269PubMed:12519826, ECO:0000269PubMed:15531542, ECO:0000269PubMed:19128366, ECO:0000269PubMed:9462743, ECO:0000269PubMed:9768691}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed specifically in embryonic pituitary.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000047
Helix-turn-helix motif
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
PR00031
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
O75360
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PhosphoSite |
PhosphoSite-O75360
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5626
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UniGene |
Hs.158301
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RefSeq |
NP_006252
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HUGO |
HGNC:9455
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OMIM |
601538
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CCDS |
CCDS4430
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HPRD |
03325
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IMGT |
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EMBL |
AC136940
AF041139
AF041140
AF041141
AF076214
AF076215
BC069076
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GenPept |
AAC27900
AAC77453
AAC77454
AAH69076
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