InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFA1

Summary

InnateDB Protein

IDBP-6085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFA1

Protein Name

defensin, alpha 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000372139

InnateDB Gene

IDBG-6083 (DEFA1)

Protein Structure

UniProt Annotation

Function

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269PubMed:15616305, ECO:0000269PubMed:17452329}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006955	immune response
GO:0019731	antibacterial humoral response
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0031640	killing of cells of other organism
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus
GO:0051607	defense response to virus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0035578	azurophil granule lumen
GO:0070062	extracellular vesicular exosome