InnateDB Protein
|
IDBP-60939.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ACY3
|
Protein Name
|
aspartoacylase (aminocyclase) 3
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000255082
|
InnateDB Gene
|
IDBG-60937 (ACY3)
|
Protein Structure
|
|
Function |
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Apical cell membrane {ECO:0000269PubMed:19486448}; Peripheral membrane protein {ECO:0000269PubMed:19486448}. Cytoplasm {ECO:0000269PubMed:19486448}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007036
Succinylglutamate desuccinylase/aspartoacylase
IPR016708
Aspartoacylase
|
PFAM |
PF04952
|
PRINTS |
|
PIRSF |
PIRSF039012
PIRSF018001
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96HD9
|
PhosphoSite |
PhosphoSite-Q96HD9
|
TrEMBL |
E9PRA7
|
UniProt Splice Variant |
|
Entrez Gene |
91703
|
UniGene |
Hs.126265
|
RefSeq |
NP_542389
|
HUGO |
HGNC:24104
|
OMIM |
614413
|
CCDS |
CCDS8175
|
HPRD |
12422
|
IMGT |
|
EMBL |
AP003385
AY040761
AY169233
BC008689
CH471076
|
GenPept |
AAH08689
AAK94770
AAN87896
EAW74663
EAW74664
|
|
|