Version 5.4
Homo sapiens Protein: ACY3
Summary
InnateDB Protein IDBP-60939.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACY3
Protein Name aspartoacylase (aminocyclase) 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000255082
InnateDB Gene IDBG-60937 (ACY3)
Protein Structure
UniProt Annotation
Function Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity). {ECO:0000250}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:19486448}; Peripheral membrane protein {ECO:0000269PubMed:19486448}. Cytoplasm {ECO:0000269PubMed:19486448}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004046 aminoacylase activity
GO:0005515 protein binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0016032 viral process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007036 Succinylglutamate desuccinylase/aspartoacylase
IPR016708 Aspartoacylase
PFAM PF04952
PRINTS
PIRSF PIRSF039012
PIRSF018001
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HD9
PhosphoSite PhosphoSite-Q96HD9
TrEMBL E9PRA7
UniProt Splice Variant
Entrez Gene 91703
UniGene Hs.126265
RefSeq NP_542389
HUGO HGNC:24104
OMIM 614413
CCDS CCDS8175
HPRD 12422
IMGT
EMBL AP003385 AY040761 AY169233 BC008689 CH471076
GenPept AAH08689 AAK94770 AAN87896 EAW74663 EAW74664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca