InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP11

Summary

InnateDB Protein

IDBP-61046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP11

Protein Name

ubiquitin specific peptidase 11

Synonyms

UHX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000218348

InnateDB Gene

IDBG-61044 (USP11)

Protein Structure

UniProt Annotation

Function

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. {ECO:0000269PubMed:15314155, ECO:0000269PubMed:17897950, ECO:0000269PubMed:18408009, ECO:0000269PubMed:19874889, ECO:0000269PubMed:20233726}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.

Experimentally validated
Total	131 [view]
Protein-Protein	129 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00443
PF06337

PRINTS

PIRSF

SMART

SM00695

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51784