InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RX4

Summary

InnateDB Protein

IDBP-61375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX4

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 4

Synonyms

P2X4; P2X4R;

Species

Homo sapiens

Ensembl Protein

ENSP00000336607

InnateDB Gene

IDBG-61373 (P2RX4)

Protein Structure

UniProt Annotation

Function

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. {ECO:0000269PubMed:10515189}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10515189}; Multi-pass membrane protein {ECO:0000269PubMed:10515189}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005102	receptor binding
GO:0005216	ion channel activity
GO:0005507	copper ion binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0045296	cadherin binding

Biological Process

GO:0001894	tissue homeostasis
GO:0002028	regulation of sodium ion transport
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0019233	sensory perception of pain
GO:0032308	positive regulation of prostaglandin secretion
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0034405	response to fluid shear stress
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042118	endothelial cell activation
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051899	membrane depolarization
GO:0051928	positive regulation of calcium ion transport
GO:0055117	regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0071318	cellular response to ATP
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome