InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPH1

Summary

InnateDB Protein

IDBP-61487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPH1

Protein Name

heterogeneous nuclear ribonucleoprotein H1 (H)

Synonyms

hnRNPH; HNRPH; HNRPH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349168

InnateDB Gene

IDBG-61485 (HNRNPH1)

Protein Structure

UniProt Annotation

Function

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269PubMed:11003644, ECO:0000269PubMed:16946708}.

Subcellular Localization

Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	161 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0044822	poly(A) RNA binding