Version 5.4
Homo sapiens Protein: LTC4S
Summary
InnateDB Protein IDBP-61662.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTC4S
Protein Name leukotriene C4 synthase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292596
InnateDB Gene IDBG-243666 (LTC4S)
Protein Structure
UniProt Annotation
Function Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
Subcellular Localization Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Disease Associations Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
Tissue Specificity Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269PubMed:7599836}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004464 leukotriene-C4 synthase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008289 lipid binding
Biological Process
GO:0006691 leukotriene metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0043085 positive regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:2001300 lipoxin metabolic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
IPR001446 5-lipoxygenase-activating protein
PFAM PF01124
PRINTS PR00488
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16873
PhosphoSite PhosphoSite-Q16873
TrEMBL B2R523
UniProt Splice Variant
Entrez Gene 4056
UniGene
RefSeq NP_665874
HUGO HGNC:6719
OMIM 246530
CCDS CCDS34316
HPRD 02004
IMGT
EMBL AK312033 BC029498 U09353 U11552 U50136 U62025
GenPept AAA20467 AAA50555 AAB06723 AAC50476 AAH29498 BAG34970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca