InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSF2RB

Summary

InnateDB Protein

IDBP-6180.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF2RB

Protein Name

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

Synonyms

CD131; CDw131; IL3RB; IL5RB; SMDP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000262825

InnateDB Gene

IDBG-6178 (CSF2RB)

Protein Structure

UniProt Annotation

Function

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Pulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269PubMed:21075760}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	44 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004896	cytokine receptor activity
GO:0004912	interleukin-3 receptor activity
GO:0004914	interleukin-5 receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007585	respiratory gaseous exchange
GO:0019221	cytokine-mediated signaling pathway
GO:0036016	cellular response to interleukin-3
GO:0038043	interleukin-5-mediated signaling pathway
GO:0038156	interleukin-3-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003961 Fibronectin, type III
IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
IPR015321 Interleukin-6 receptor alpha, binding
IPR015373 Interferon alpha/beta receptor, beta chain

PFAM

PF00041
PF01108
PF09240
PF09294

PRINTS

PIRSF

PIRSF001956

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt