Version 5.4
Mus musculus Protein: Adrbk1
Summary
InnateDB Protein IDBP-619822.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adrbk1
Protein Name adrenergic receptor kinase, beta 1
Synonyms Adrbk-1; Bark-1; beta ARK; betaARK1; GRK2;
Species Mus musculus
Ensembl Protein ENSMUSP00000126930
InnateDB Gene IDBG-129419 (Adrbk1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0006468 protein phosphorylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:87940
InterPro IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00615
PF00069
PF07714
PRINTS PR00717
PR01301
PR00109
PIRSF
SMART SM00220
SM00315
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PW16
UniProt Splice Variant
Entrez Gene 110355
UniGene Mm.254144
RefSeq
MGI ID
MGI Symbol Adrbk1
OMIM
CCDS
HPRD
IMGT
EMBL AC140073
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca