InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bscl2

Summary

InnateDB Protein

IDBP-619912.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bscl2

Protein Name

Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)

Synonyms

2900097C17Rik; AI046355; Gng3lg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127685

InnateDB Gene

IDBG-141270 (Bscl2)

Protein Structure

UniProt Annotation

Function

Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis. {ECO:0000269PubMed:18458148, ECO:0000269PubMed:19574402, ECO:0000269PubMed:21551454, ECO:0000269PubMed:22269949}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19574402}; Multi-pass membrane protein {ECO:0000269PubMed:19574402}.

Disease Associations

Tissue Specificity

Expressed in the paraventricular nucleus of the hypothalamus (PVN) and brainstem dorsal vagal complex (DVC) in oxytocin and catecholaminergic neurons (at protein level). Highest expression detected in subcutaneous and epididymal white adipose tissue, brown adipose tissue and testis. Also expressed in brain, skeletal muscle and adrenal gland, with lower levels detected in liver, heart, kidney, spleen, lung and small intestine. In brain, detected in piriform cortex, olfactory tubercle, islands of Calleja, lateral septal nucleus, medial septal nucleus, nucleus of the vertical limb of the diagonal band, nucleus of the horizontal limb of the diagonal band, preoptic area, paraventricular thalamic nucleus, lateral globus pallidus, supraoptic nucleus, suprachiasmatic nucleus, subfornical organ, paraventricular nucleus of the hypothalamus, zona incerta, dorsomedial nucleus of the hypothalamus, ventromedial nucleus of the hypothalamus, arcuate nucleus of the hypothalamus, basomedial amygdaloid nucleus, medial amygdaloid nucleus, medial habenular, pyramidal cell layer of the hippocampus, granular layer of the dentate gyrus, posterior hypothalamus, supramammilliary nucleus, premammillary nucleus, nucleus of Darkschewitsch, Edinger-Westphal nucleus, ventral tegmental area, dorsal raphe nucleus, periaqueductal gray, median raphe nucleus, lateral parabrachial nucleus, dorsal tegmental nucleus, laterodorsal tegmental nucleus, locus coeruleus, Barrington's nucleus, medial vestibular nucleus, ambiguous nucleus, dorsal vagal complex and hypoglossal nucleus. {ECO:0000269PubMed:18458148, ECO:0000269PubMed:19574402, ECO:0000269PubMed:23049863, ECO:0000269PubMed:9790771}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0016042	lipid catabolic process
GO:0019915	lipid storage
GO:0034389	lipid particle organization
GO:0045444	fat cell differentiation
GO:0050995	negative regulation of lipid catabolic process