Version 5.4
Homo sapiens Protein: SPAG6
Summary
InnateDB Protein IDBP-61997.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG6
Protein Name sperm associated antigen 6
Synonyms CT141; pf16; Repro-SA-1;
Species Homo sapiens
Ensembl Protein ENSP00000365788
InnateDB Gene IDBG-61993 (SPAG6)
Protein Structure
UniProt Annotation
Function Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:10493827}. Cell projection, cilium, flagellum {ECO:0000269PubMed:10493827}. Note=Associated with microtubules. Detected on the sperm flagellum.
Disease Associations
Tissue Specificity Highly expressed in testis. {ECO:0000269PubMed:10493827}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0007286 spermatid development
GO:0030030 cell projection organization
Cellular Component
GO:0005634 nucleus
GO:0005874 microtubule
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000225 Armadillo
IPR000357 HEAT
IPR016024 Armadillo-type fold
IPR019538 26S proteasome non-ATPase regulatory subunit 5
PFAM PF00514
PF02985
PF10508
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75602
PhosphoSite PhosphoSite-O75602
TrEMBL
UniProt Splice Variant
Entrez Gene 9576
UniGene
RefSeq NP_001240784
HUGO HGNC:11215
OMIM 605730
CCDS CCDS73072
HPRD 09305
IMGT
EMBL AF079363 AK289903 AK302194 AL080136 AL158211 AL513128 BC030585 CH471072 CR533552
GenPept AAC32590 AAH30585 BAF82592 BAG63556 CAB45730 CAG38583 CAH72207 CAH72208 CAH72209 CAH72210 CAI15960 CAI15961 CAI15962 CAI15963 EAW86146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca