Version 5.4
Mus musculus Protein: Diap3
Summary
InnateDB Protein IDBP-620537.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Diap3
Protein Name diaphanous homolog 3 (Drosophila)
Synonyms 4930417P13Rik; Dia2; Diaph3; Drf3; mDia2; mKIAA4117; p134MDia2;
Species Mus musculus
Ensembl Protein ENSMUSP00000129420
InnateDB Gene IDBG-183244 (Diap3)
Protein Structure
UniProt Annotation
Function Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. {ECO:0000269PubMed:10678165}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Note=During mitosis, colocalizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007283 spermatogenesis
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1927222
InterPro IPR010465 DRF autoregulatory
IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF06345
PF06367
PF06371
PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z207
PhosphoSite PhosphoSite-Q9Z207
TrEMBL Q3UVP0
UniProt Splice Variant
Entrez Gene 56419
UniGene Mm.440585
RefSeq NP_062644
MGI ID
MGI Symbol Diap3
OMIM
CCDS CCDS36990
HPRD
IMGT
EMBL AF094519 AK137073 AK138694 AK161737
GenPept AAC71771 BAE23229 BAE23751 BAE36554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca