InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo9b

Summary

InnateDB Protein

IDBP-620661.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo9b

Protein Name

myosin IXb

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129220

InnateDB Gene

IDBG-164984 (Myo9b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0043008	ATP-dependent protein binding
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0002548	monocyte chemotaxis
GO:0006200	ATP catabolic process
GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0030010	establishment of cell polarity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0048246	macrophage chemotaxis
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030027	lamellipodium
GO:0031941	filamentous actin
GO:0032433	filopodium tip
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:106624

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001609 Myosin head, motor domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM

PF00612
PF00788
PF00620
PF00063
PF00130

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00314
SM00324
SM00242
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt