InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk6

Summary

InnateDB Protein

IDBP-621018.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk6

Protein Name

cyclin-dependent kinase 6

Synonyms

5830411I20; AI504062; Crk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126024

InnateDB Gene

IDBG-131439 (Cdk6)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. {ECO:0000269PubMed:16767702, ECO:0000269PubMed:21319271, ECO:0000269PubMed:21508411}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) of the lateral ventricles whose neural precursor cells (NPC) give rise to dentate granule neurons and olfactory bulb (OB) interneurons, respectively. {ECO:0000269PubMed:21319271}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	19 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007219	Notch signaling pathway
GO:0010628	positive regulation of gene expression
GO:0030097	hemopoiesis
GO:0033077	T cell differentiation in thymus
GO:0042127	regulation of cell proliferation
GO:0043697	cell dedifferentiation
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division
GO:0060218	hematopoietic stem cell differentiation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1277162

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt