InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbln1

Summary

InnateDB Protein

IDBP-621299.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbln1

Protein Name

cerebellin 1 precursor protein

Synonyms

AI323299;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126575

InnateDB Gene

IDBG-178238 (Cbln1)

Protein Structure

UniProt Annotation

Function

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion. {ECO:0000269PubMed:16234806, ECO:0000269PubMed:17030622, ECO:0000269PubMed:17331201, ECO:0000269PubMed:20395510, ECO:0000269PubMed:21410790, ECO:0000269PubMed:23141067}.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Cell junction, synapse, postsynaptic cell membrane. Note=Interaction with CBLN3 may cause partial retention in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Expressed and secreted by presynaptic neurons, such as cerebellar granule cells. Following secretion, the protein binds to GRID2 on the postsynaptic Purkinje cell membranes. Expressed at the highest level in the cerebellar cortex. High levels are also seen in the olfactory bulb, posterior part of the cerebral cortex, certain thalamic nuclei, and deep cerebellar nuclei. Low to moderate levels are detected in some hypothalamic and brainstem nuclei. In the thalamus, expressed in parafascicular nucleus neurons and other regions (at protein level). {ECO:0000269PubMed:16930405, ECO:0000269PubMed:17030622, ECO:0000269PubMed:22220752, ECO:0000269PubMed:23141067, ECO:0000269PubMed:3199194, ECO:0000269PubMed:3420533}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0009306	protein secretion
GO:0021707	cerebellar granule cell differentiation
GO:0051965	positive regulation of synapse assembly