InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cep55

Summary

InnateDB Protein

IDBP-621326.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cep55

Protein Name

centrosomal protein 55

Synonyms

1200008O12Rik; 2700032M20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127961

InnateDB Gene

IDBG-162559 (Cep55)

Protein Structure

UniProt Annotation

Function

Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. Dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007067	mitotic nuclear division
GO:0045184	establishment of protein localization

Cellular Component

GO:0005813	centrosome
GO:0005814	centriole
GO:0016020	membrane
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

MGI:1921357

InterPro

IPR022008 TSG101 and ALIX binding domain of CEP55

PFAM

PF12180

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BT07

PhosphoSite

PhosphoSite-Q8BT07

TrEMBL

UniProt Splice Variant

Entrez Gene

74107

UniGene

Mm.9916

RefSeq

NP_001157834

MGI ID

MGI Symbol

Cep55

OMIM

CCDS

CCDS50429

HPRD

IMGT

EMBL

AK004655 AK028216 AK088548 BC026966 BC031396

GenPept

AAH26966 AAH31396 BAB23446 BAC25819 BAC40417