InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrxn3

Summary

InnateDB Protein

IDBP-621525.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrxn3

Protein Name

neurexin III

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129678

InnateDB Gene

IDBG-160964 (Nrxn3)

Protein Structure

UniProt Annotation

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain and arteries (at protein level). {ECO:0000269PubMed:19926856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007416	synapse assembly
GO:0007612	learning
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0051965	positive regulation of synapse assembly
GO:0071625	vocalization behavior
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0016021	integral component of membrane
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1096389

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR003585 Neurexin/syndecan/glycophorin C
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00054
PF02210

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00294

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P9K9