Version 5.4
Mus musculus Protein: Apc
Summary
InnateDB Protein IDBP-621763.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apc
Protein Name adenomatosis polyposis coli
Synonyms AI047805; AU020952; AW124434; CC1; mAPC; Min;
Species Mus musculus
Ensembl Protein ENSMUSP00000127131
InnateDB Gene IDBG-134573 (Apc)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 133 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 35 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 133 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0051010 microtubule plus-end binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001822 kidney development
GO:0001942 hair follicle development
GO:0006974 cellular response to DNA damage stimulus
GO:0007026 negative regulation of microtubule depolymerization
GO:0007050 cell cycle arrest
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell proliferation
GO:0009798 axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0019827 stem cell maintenance
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0033077 T cell differentiation in thymus
GO:0035019 somatic stem cell maintenance
GO:0042483 negative regulation of odontogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043409 negative regulation of MAPK cascade
GO:0043588 skin development
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045785 positive regulation of cell adhesion
GO:0046716 muscle cell cellular homeostasis
GO:0048538 thymus development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051171 regulation of nitrogen compound metabolic process
GO:0051276 chromosome organization
GO:0051726 regulation of cell cycle
GO:0051781 positive regulation of cell division
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0060041 retina development in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005881 cytoplasmic microtubule
GO:0030424 axon
GO:0030426 growth cone
GO:0031253 cell projection membrane
GO:0035371 microtubule plus-end
GO:0042995 cell projection
GO:0044295 axonal growth cone
Protein Structure and Domains
PDB ID MGI:88039
InterPro IPR000225 Armadillo
IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
IPR016024 Armadillo-type fold
IPR026831 Adenomatous polyposis coli domain
PFAM PF00514
PF05972
PF11414
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q4H1
UniProt Splice Variant
Entrez Gene 11789
UniGene Mm.470430
RefSeq
MGI ID
MGI Symbol Apc
OMIM
CCDS
HPRD
IMGT
EMBL AC090534 AC114003 AL591373
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca