InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pax2

Summary

InnateDB Protein

IDBP-621773.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax2

Protein Name

paired box gene 2

Synonyms

Opdc; Pax-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134661

InnateDB Gene

IDBG-170108 (Pax2)

Protein Structure

UniProt Annotation

Function

Probable transcription factor that may have a role in kidney cell differentiation.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Pax2 are a cause of developmental defects of the kidney, brain, ear and eye. {ECO:0000269PubMed:8943028}.

Tissue Specificity

Kidney and nephrogenic rests.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0044212	transcription regulatory region DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001655	urogenital system development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001709	cell fate determination
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0001843	neural tube closure
GO:0002072	optic cup morphogenesis involved in camera-type eye development
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003406	retinal pigment epithelium development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0007501	mesodermal cell fate specification
GO:0007568	aging
GO:0010001	glial cell differentiation
GO:0021554	optic nerve development
GO:0021631	optic nerve morphogenesis
GO:0021633	optic nerve structural organization
GO:0021650	vestibulocochlear nerve formation
GO:0031016	pancreas development
GO:0031667	response to nutrient levels
GO:0035566	regulation of metanephros size
GO:0035799	ureter maturation
GO:0039003	pronephric field specification
GO:0042472	inner ear morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043067	regulation of programmed cell death
GO:0043069	negative regulation of programmed cell death
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491	protein kinase B signaling
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045918	negative regulation of cytolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048793	pronephros development
GO:0048854	brain morphogenesis
GO:0048863	stem cell differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0055114	oxidation-reduction process
GO:0060231	mesenchymal to epithelial transition
GO:0061205	paramesonephric duct development
GO:0061360	optic chiasma development
GO:0070301	cellular response to hydrogen peroxide
GO:0071260	cellular response to mechanical stimulus
GO:0071300	cellular response to retinoic acid
GO:0071333	cellular response to glucose stimulus
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072001	renal system development
GO:0072075	metanephric mesenchyme development
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072162	metanephric mesenchymal cell differentiation
GO:0072164	mesonephric tubule development
GO:0072172	mesonephric tubule formation
GO:0072177	mesonephric duct development
GO:0072179	nephric duct formation
GO:0072189	ureter development
GO:0072197	ureter morphogenesis
GO:0072205	metanephric collecting duct development
GO:0072207	metanephric epithelium development
GO:0072221	metanephric distal convoluted tubule development
GO:0072289	metanephric nephron tubule formation
GO:0072300	positive regulation of metanephric glomerulus development
GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0072593	reactive oxygen species metabolic process
GO:0090102	cochlea development
GO:0090103	cochlea morphogenesis
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000378	negative regulation of reactive oxygen species metabolic process
GO:2000594	positive regulation of metanephric DCT cell differentiation
GO:2000597	positive regulation of optic nerve formation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005764	lysosome
GO:0005815	microtubule organizing center
GO:0032993	protein-DNA complex
GO:0034451	centriolar satellite
GO:0043234	protein complex