Version 5.4
Homo sapiens Protein: IL31
Summary
InnateDB Protein IDBP-62193.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL31
Protein Name interleukin 31
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366234
InnateDB Gene IDBG-62191 (IL31)
Protein Structure
UniProt Annotation
Function Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. {ECO:0000269PubMed:15184896}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. {ECO:0000269PubMed:15184896}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0002376 immune system process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6EBC2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 386653
UniGene Hs.569071
RefSeq NP_001014358
HUGO HGNC:19372
OMIM 609509
CCDS CCDS31919
HPRD 11877
IMGT
EMBL AY499343 BC132998 BC133000
GenPept AAI32999 AAI33001 AAS86448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca