Version 5.4
| Mus musculus Protein: Rbm20 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-622284.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Rbm20 | ||||||||||
| Protein Name | RNA binding motif protein 20 | ||||||||||
| Synonyms | 1110018J23Rik; 2010003H22Rik; AI646761; | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000129447 | ||||||||||
| InnateDB Gene | IDBG-176852 (Rbm20) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin). {ECO:0000269PubMed:22466703}. | ||||||||||
| Subcellular Localization | Nucleus {ECO:0000269PubMed:22466703}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Predominantly expressed in striated muscle, with highest expression in the heart. In differentiating myoblasts, expression correlates with sarcomere assembly: expression peaks when alpha-actinin is localized mainly in mature Z bodies within the nascent myofiber and expression declines as the sarcomeres continue to mature. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1920963 | ||||||||||
| InterPro |
IPR000504
RNA recognition motif domain IPR000690 Zinc finger, C2H2-type matrin IPR003604 Zinc finger, U1-type |
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| PFAM |
PF00076
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00360
SM00451 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q3UQS8 | ||||||||||
| PhosphoSite | PhosphoSite-Q3UQS8 | ||||||||||
| TrEMBL | E9QPB0 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 73713 | ||||||||||
| UniGene | Mm.489950 | ||||||||||
| RefSeq | NP_001164318 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Rbm20 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS50468 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AC117805 AC121510 AC137853 AK142175 BC038663 | ||||||||||
| GenPept | AAH38663 BAE24961 | ||||||||||