Version 5.4
Mus musculus Protein: Ppp1r15a
Summary
InnateDB Protein IDBP-622556.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r15a
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 15A
Synonyms 9630030H21; Gadd34; Myd116;
Species Mus musculus
Ensembl Protein ENSMUSP00000128497
InnateDB Gene IDBG-183552 (Ppp1r15a)
Protein Structure
UniProt Annotation
Function Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication. {ECO:0000269PubMed:11381086, ECO:0000269PubMed:12606582, ECO:0000269PubMed:12824288, ECO:0000269PubMed:16478986, ECO:0000269PubMed:17670836}.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed strongly in spleen and lung, moderately in thymus and muscle, and weakly in brain. {ECO:0000269PubMed:12824288}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019901 protein kinase binding
Biological Process
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0030968 endoplasmic reticulum unfolded protein response
Cellular Component
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:1927072
InterPro IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
PFAM PF10488
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17564
PhosphoSite PhosphoSite-
TrEMBL B2RRL7
UniProt Splice Variant
Entrez Gene 17872
UniGene Mm.4048
RefSeq
MGI ID
MGI Symbol Ppp1r15a
OMIM
CCDS CCDS21249
HPRD
IMGT
EMBL AK079339 AK154697 AK167317 BC138485 BC138486 CH466603 X51829
GenPept AAI38486 AAI38487 BAC37613 BAE32770 BAE39419 CAA36128 EDL22865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca