InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drosha

Summary

InnateDB Protein

IDBP-623274.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drosha

Protein Name

drosha, ribonuclease type III

Synonyms

1110013A17Rik; AI874853; Etohi2; Rn3; Rnasen;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129279

InnateDB Gene

IDBG-130254 (Drosha)

Protein Structure

UniProt Annotation

Function

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006396	RNA processing
GO:0010468	regulation of gene expression
GO:0010586	miRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0031053	primary miRNA processing
GO:0031054	pre-miRNA processing
GO:0042254	ribosome biogenesis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic