Version 5.4
Mus musculus Protein: Jph3
Summary
InnateDB Protein IDBP-623352.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jph3
Protein Name junctophilin 3
Synonyms JP-3; Jp3;
Species Mus musculus
Ensembl Protein ENSMUSP00000126190
InnateDB Gene IDBG-196770 (Jph3)
Protein Structure
UniProt Annotation
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. {ECO:0000269PubMed:11906164, ECO:0000269PubMed:16809425}.
Subcellular Localization Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
Disease Associations
Tissue Specificity Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinge cells, while it is weakly expressed in granular cells. {ECO:0000269PubMed:11906164, ECO:0000269PubMed:16809425}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015278 calcium-release channel activity
Biological Process
GO:0007612 learning
GO:0007613 memory
GO:0035640 exploration behavior
GO:0040011 locomotion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0050885 neuromuscular process controlling balance
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030314 junctional membrane complex
Protein Structure and Domains
PDB ID MGI:1891497
InterPro IPR003409 MORN motif
IPR017191 Junctophilin
PFAM PF02493
PRINTS
PIRSF PIRSF037387
SMART SM00698
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ET77
PhosphoSite PhosphoSite-Q9ET77
TrEMBL
UniProt Splice Variant
Entrez Gene 57340
UniGene Mm.418668
RefSeq
MGI ID
MGI Symbol Jph3
OMIM
CCDS CCDS22728
HPRD
IMGT
EMBL AB024449 AB024450 AK082880 BC103682 BC104736 BC105307
GenPept AAI03683 AAI04737 AAI05308 BAB12046 BAB20320 BAC38666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca