InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nedd4l

Summary

InnateDB Protein

IDBP-623398.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nedd4l

Protein Name

neural precursor cell expressed, developmentally down-regulated gene 4-like

Synonyms

1300012C07Rik; Nedd4-2; Nedd4b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132838

InnateDB Gene

IDBG-154290 (Nedd4l)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 140 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	140 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0016874	ligase activity
GO:0017080	sodium channel regulator activity
GO:0019870	potassium channel inhibitor activity
GO:0019871	sodium channel inhibitor activity
GO:0044325	ion channel binding

Biological Process

GO:0003085	negative regulation of systemic arterial blood pressure
GO:0003254	regulation of membrane depolarization
GO:0006513	protein monoubiquitination
GO:0009651	response to salt stress
GO:0010038	response to metal ion
GO:0010765	positive regulation of sodium ion transport
GO:0010766	negative regulation of sodium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045732	positive regulation of protein catabolic process
GO:0060306	regulation of membrane repolarization
GO:0070936	protein K48-linked ubiquitination
GO:0086005	ventricular cardiac muscle cell action potential
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:1902306	negative regulation of sodium ion transmembrane transport
GO:2000009	negative regulation of protein localization to cell surface
GO:2000650	negative regulation of sodium ion transmembrane transporter activity
GO:2000810	regulation of tight junction assembly
GO:2001259	positive regulation of cation channel activity
GO:2001288	positive regulation of caveolin-mediated endocytosis