Version 5.4
Mus musculus Protein: Smad2
Summary
InnateDB Protein IDBP-623825.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad2
Protein Name MAD homolog 2 (Drosophila)
Synonyms 7120426M23Rik; Madh2; Madr2; mMad2; Smad-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000132851
InnateDB Gene IDBG-159056 (Smad2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 306 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 51 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 306 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007492 endoderm development
GO:0007507 heart development
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009952 anterior/posterior pattern specification
GO:0030073 insulin secretion
GO:0030324 lung development
GO:0031016 pancreas development
GO:0035265 organ growth
GO:0035556 intracellular signal transduction
GO:0045165 cell fate commitment
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051098 regulation of binding
GO:0060039 pericardium development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:108051
InterPro IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
PFAM PF03165
PRINTS
PIRSF
SMART SM00523
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PXA8
UniProt Splice Variant
Entrez Gene 17126
UniGene Mm.407276
RefSeq
MGI ID
MGI Symbol Smad2
OMIM
CCDS
HPRD
IMGT
EMBL AC107768 AC164009
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca